# The injection that could replace weeks of chemo: in vivo CAR-T enters the autoimmune clinic

- slug: the-injection-that-could-replace-weeks-of-chemo-in-vivo-car-t-enters-the-autoimmune-clinic
- date: 2026-04-15
- category: Biotech & Life Sciences

Standard CAR-T for autoimmune disease requires weeks of chemotherapy and ICU-level care. An injection without preconditioning just showed deep B-cell depletion in lymph node tissue for the first time, with a manufacturing scale that could make it a platform, not a trial.

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