# AstraZeneca's next-gen hopeful for a rare bone condition fails pivotal trial

- slug: astrazenecas-next-gen-hopeful-for-a-rare-bone-condition-fails-pivotal-trial
- date: 2026-03-31
- category: Biotech & Life Sciences

AstraZeneca called it a success. The adult HPP trial missed its goal—but a subgroup of patients who developed the disease as children did show benefit. The problem: 80 percent of HPP patients are adults.

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