# Weight-Loss Shots Show Growing Muscle-Loss Gap Over Time, Study Finds - Date: 2026-04-17 - Category: Biotech & Life Sciences A real-world study of 8,000 patients found tirzepatide users lost roughly 10% more lean body mass than semaglutide users at one year. Neither drug warns about this difference on its label, and it falls hardest on older patients already vulnerable to muscle loss. ---