# Flagship Put a $50 Million Bet That Could Upend Gene Therapy Biggest Moats - Date: 2026-04-21 - Category: Biotech & Life Sciences Flagship just committed $50M to Serif Biomedicines, a new gene therapy company run by Jake Rubens. The bet: cracking delivery, the field is oldest unsolved problem. If he succeeds, the rare-disease moats that made Spark ($4.3B) and uniQure billion-dollar prizes may not survive. ---